PE-22-28 is a synthetic derivative of the natural peptide Spadin. This chemical binds to TREK-1. TREK-1 is commonly found in the brain and may even be present in some parts of the heart, smooth muscle tissue, lung, prostate, and pancreas. TREK-1 is normally located in the area of ​​the brain that controls emotion. PE-22-28 is being studied for its ability to address mental health issues. This synthetic compound may provide antidepressant activity, learning ability, and stroke recovery. Small-scale studies have even suggested that PE-22-28 could be a future treatment for neurodegenerative diseases such as Alzheimer’s disease.