KPV is a naturally occurring peptide found in the hormone α-MSH (Melanocyte Stimulating Hormone) that has the potential to improve gut inflammation and gut health. It also addresses conditions like inflammatory bowel disease (IBD) and colon cancer. With its so-called anti-inflammatory properties, KPV has the potential to alleviate immune-mediated inflammatory diseases. It also modulates the gut microbiota and enhances gut barrier function, making it attractive for gut health interventions. Furthermore, the ability of KPV to inhibit tumor growth and induce apoptosis in cancer cells suggests a possible therapeutic role in the treatment of colon cancer.